Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells

Abstract Background iPSC (induced pluripotent stem cells) banks of lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation derived cell therapies. Cord blood offer extensive source HLA-typed cells suitable for reprogramming iPSC. Several initiatives worldwide have been undertaken create national international haplobanks that match a significant part population. Methods To haplobank serves the Spanish population (IPS-PANIA), we searched Bone Marrow Donor Registry (REDMO) identify most frequently estimated haplotypes. From top ten donors identified, coverage using criteria zero mismatches in HLA-A, HLA-B, HLA-DRB1 different stringencies: high resolution, low beneficial mismatch. Results We calculated cord units from stored at can provide matching 28.23% Conclusion confirm feasibility banked will cover percentage future advanced therapy replacement strategies.